Search results for "enhancer blocker"

Down-regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5' and 3' regions and including the enhancer b…

2004

The tandem repeated sea urchin alpha-histone genes are developmentally regulated by gene-specific promoter elements. Coordinate transcription of the five genes begins after meiotic maturation of the oocyte, continues through cleavage, and reaches its maximum at morula stage, after which these genes are shut off and maintained in a silenced state for the life cycle of the animal. Although cis regulative sequences affecting the timing and the level of expression of these genes have been characterized, much less is known about the mechanism of their repression. Here we report the results of a functional analysis that allowed the identification of the sequence elements needed for the silencing …

Caratterizzazione funzionale e strutturale di un isolatore cromatinico localizzato tra i geni c-Myc e Pvt-1 umani

2008

Thanatos associated protein 11 (THAP11) modulates expression of c-MYC by binding the HB2.8 enhancer blocker element.

2014